H. pylori Eradication

⚕️ Helicobacter pylori Eradication Therapy: Key Molecules & Brands in India

🔹 Introduction

Helicobacter pylori (H. pylori) ek common bacteria hai jo stomach lining mein infection karta hai. Ye infection:

  • Peptic ulcer disease (stomach & duodenal ulcers)
  • Chronic gastritis
  • Gastric cancer (long-term risk) se closely associated hai.

Isko treat karna zaruri hai, aur doctors Triple therapy ya Quadruple therapy recommend karte hain, jisme PPI (Proton Pump Inhibitor) ke saath antibiotics aur bismuth compounds diye jaate hain.

🔹 Key Molecules in H. pylori Eradication

✦ Clarithromycin

  • Brands: Clarithro, Klacid
  • Use: Macrolide antibiotic, backbone of triple therapy
  • Note: Resistance in some regions, so efficacy may vary

✦ Amoxicillin

  • Brands: Mox, Amoxil
  • Use: Broad-spectrum penicillin antibiotic
  • Note: Generally well-tolerated; used in almost all regimens unless patient allergic to penicillin

✦ Metronidazole

  • Brand: Flagyl
  • Use: Nitroimidazole antibiotic, alternative in resistant cases
  • Note: Metallic taste, alcohol interaction (disulfiram-like reaction)

✦ Tinidazole

  • Brand: Tiniba
  • Use: Similar to metronidazole, sometimes used in combination therapy
  • Note: Better compliance due to longer half-life

✦ Bismuth Compounds

  • Brand: De-Nol (Colloidal bismuth subcitrate)
  • Use: Protects stomach lining & enhances eradication rates
  • Note: Mainly used in quadruple therapy

🔹 Therapy Regimens

1. Triple Therapy (10–14 days)

  • PPI (Pantoprazole / Esomeprazole) + Clarithromycin + Amoxicillin (or Metronidazole if penicillin allergy)

2. Quadruple Therapy (10–14 days)

  • PPI + Bismuth compound + Metronidazole/Tinidazole + Tetracycline (or Clarithromycin)

3. Sequential / Concomitant Therapy

  • Used in resistant cases, combining multiple antibiotics with PPI

📝 Conclusion

H. pylori eradication ke liye:

  • Triple therapy standard hai (PPI + Clarithromycin + Amoxicillin)
  • Quadruple therapy bismuth ke saath use hoti hai jab resistance ya recurrence hota hai
  • Proper compliance (10–14 days) zaruri hai warna resistance develop ho sakta hai.

⚠️ Disclaimer

This article is for educational purposes only. It does not replace medical advice. Always consult a gastroenterologist before starting H. pylori eradication therapy.

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