🫀 Heart Failure Drugs: Essential Therapies in Cardiology
🔹 Introduction
Heart Failure (HF) ek chronic aur progressive condition hai jisme dil effectively pump nahi kar pata. Iske treatment mein naye drugs ne patient outcomes drastically improve kiye hain.
🔹 Key Drugs in Heart Failure
(A) ARNI (Sacubitril + Valsartan)
- Brand Example: Entresto
- Mechanism: Neprilysin inhibition + RAAS blockade
- Use: HFrEF (Heart Failure with reduced ejection fraction)
- Benefit: Game-changer – reduces hospitalizations & mortality
(B) SGLT2 Inhibitors
- Examples: Dapagliflozin, Empagliflozin
- Use: Initially diabetes drugs, ab HF therapy standard ban chuki
- Benefit: Symptom improvement + reduced risk of HF hospitalization
(C) Ivabradine
- Mechanism: Selectively reduces heart rate (If channel blocker)
- Use: HFrEF patients with HR > 70 despite beta-blocker use
- Benefit: Improves exercise tolerance & reduces rehospitalization
(D) Digoxin
- Mechanism: Positive inotrope + AV node conduction slowing
- Use: HF with Atrial Fibrillation
- Caution: Narrow safety margin, risk of toxicity
📝 Conclusion
Heart failure ke treatment mein ARNI & SGLT2 inhibitors ne paradigm shift kiya hai. Ivabradine aur Digoxin selected patients ke liye valuable hain. Correct drug selection har patient ke clinical profile par depend karta hai.
⚠️ Disclaimer
This blog is for educational purposes only and not a substitute for medical advice. Always consult your doctor before starting or changing medication.